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- * Protein kinase C phosphorylation site *
- *****************************************
-
- In vivo, protein kinase C exhibits a preference for the phosphorylation of
- serine or threonine residues found close to a C-terminal basic residue [1,2].
- The presence of additional basic residues at the N- or C-terminal of the
- target amino acid enhances the Vmax and Km of the phosphorylation reaction.
-
- -Consensus pattern: [ST]-x-[RK]
- [S or T is the phosphorylation site]
- -Last update: June 1988 / First entry.
-
- [ 1] Woodget J.R., Gould K.L., Hunter T.
- Eur. J. Biochem. 161:177-184(1986).
- [ 2] Kishimoto A., Nishiyama K., Nakanishi H., Uratsuji Y., Nomura H.,
- Takeyama Y., Nishizuka Y.
- J. Biol. Chem. 260:12492-12499(1985).
-